RT Journal Article
SR Electronic
T1 Long-term effects of lung cancer CT screening on health-related quality of life (NELSON)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj01234-2010
DO 10.1183/09031936.00123410
A1 K.A.M. van den Bergh
A1 M-L. Essink-Bot
A1 G.J.J.M. Borsboom
A1 E.T. Scholten
A1 R.J. van Klaveren
A1 H.J. de Koning
YR 2010
UL http://erj.ersjournals.com/content/early/2010/12/09/09031936.00123410.abstract
AB The long-term effects of lung cancer CT screening on health-related quality of life (HRQoL) have not yet been investigated.In the lung cancer CT screening trial (NELSON), 1466 participants received questionnaires: before randomization (T0), 2 months after baseline screening (the screengroup only) (T1), and at 2-years follow-up (T2). HRQoL was measured as generic HRQoL (12-item Short Form [SF-12], EuroQoL questionnaire [EQ-5D]), anxiety (State Trait Anxiety Inventory [STAI-6]), and lung cancer-specific distress (Impact of Event Scale [IES]). Repeated measures ANOVA, were used to analyse differences between screen and controlgroup, and between indeterminate (requiring a follow-up CT) and negative screening result groups.At T0 and T2 there were no significant differences in HRQoL scores over time between the screen and control group, or between the indeterminate or negative second round screening result group. There was a temporary increase in IES scores after an indeterminate baseline result: mean (95% Confidence Interval) at T0: 4.0 (2.8–5.3), T1: 7.8 (6.5–9.0), and T2: 4.5 (3.3–5.8).At 2-years follow-up the HRQoL of screened subjects was similar to that of control subjects, the unfavorable short-term effects of an indeterminate baseline screening result had resolved, and an indeterminate result at the second screening round had no impact on HRQoL.