TY - JOUR T1 - Inhaled corticosteroids and lower lung function decline in young children with cystic fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00077210 SP - erj00772-2010 AU - K. De Boeck AU - F. Vermeulen AU - S. Wanyama AU - M. Thomas Y1 - 2010/01/01 UR - http://erj.ersjournals.com/content/early/2010/11/11/09031936.00077210.abstract N2 - A recent American registry analysis in CF children showed less lung function decline after starting ICS use. We therefore examined the influence of ICS treatment on lung function in Belgian CF patients.Data from patients ≥6 years were eligible provided entries on lung function, height and ICS use were available in 2 consecutive years. Data after oral steroid use or transplant were excluded.852 subjects contributed data with 2976 data pairs analysed, 44.9 % concerning years of ICS use. Yearly % predicted decline in forced expiratory volume in one second (FEV1) was 1.07 % lower during ICS use (p=0.001). Subgroup analysis for age revealed that the lower FEV1decline rate during ICS use was only statistically significant in children 6–12 years (2.56 %; p=0.0003). Baseline FEV1 was lower by 5.89 % (p<0.0001) in ICS users for all age groups combined but there was no difference in baseline lung function in the children 6–12 years.In 6–12 year old children with CF, baseline lung function was similar in ICS users and non users but annualized FEV1 decline was 2.56% predicted lower in ICS users. Our data therefore support recent American findings. ER -