RT Journal Article
SR Electronic
T1 Sleep-disordered breathing in neuromuscular disease with diaphragm paralysis questionnaire
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00362-2010
DO 10.1183/09031936.00036210
A1 J. Steier
A1 C. Jolley
A1 J. Seymour
A1 H. Teschler
A1 Y. Luo
A1 M.I. Polkey
A1 J. Moxham
YR 2010
UL http://erj.ersjournals.com/content/early/2010/07/01/09031936.00036210.abstract
AB Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) following respiratory muscle involvement. We hypothesised that a questionnaire based on clinical symptoms and signs of diaphragm weakness can be used to screen for SDB in such patients.We developed a self-administered multiple choice questionnaire containing five questions (SiNQ-5), scoring 0–10 points. 125 patients were enroled, 32 with respiratory muscle weakness, 35 subjects with normal respiratory muscle strength, and 58 patients with obstructive sleep apnoea (OSA). All subjects underwent full polysomnography.NMD patients with involvement of the respiratory muscles scored 6.8(2.3) out of 10 points, significantly higher than both OSA patients (2.5(2.3)) and normal subjects (1.0(2.0), p<0.001). A score of five or more points in the SiNQ-5 had a sensitivity of 86.2%, specificity of 88.5%, positive predictive value of 69.4%, and a negative predictive value of 95.5% to identify NMD with combined SDB.A short self-administered questionnaire, the SiNQ-5, based on clinical symptoms can reliably screen for SDB in patients with diaphragm weakness. However, comorbidities, such as heart failure, that have symptoms influenced by posture could alter diagnostic accuracy.