PT  - JOURNAL ARTICLE
AU  - J-P. Baguet
AU  - G. Barone-Rochette
AU  - P. Lévy
AU  - E. Vautrin
AU  - H. Pierre
AU  - O. Ormezzano
AU  - J-L. Pépin
TI  - Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoea
AID  - 10.1183/09031936.00165709
DP  - 2010 Jan 01
TA  - European Respiratory Journal
PG  - erj01657-2009
4099  - http://erj.ersjournals.com/content/early/2010/06/18/09031936.00165709.short
4100  - http://erj.ersjournals.com/content/early/2010/06/18/09031936.00165709.full
AB  - Obstructive sleep apnoea has been related to increased cardiovascular risk. The present study examined the relationships between respiratory parameters and left ventricular abnormalities in obstructive sleep apnoea.One hundred and fifty newly diagnosed OSA patients without any known cardiovascular disease were included (age =49±11 years, BMI =27.1±3.3 kg·m−2, respiratory disturbance index =41±18/h). Haemodynamic, biological, respiratory, cardiac and arterial parameters were assessed at inclusion.Thirty-four patients (22.7%) had a grade 1 left ventricular diastolic dysfunction. Patients with an abnormal diastole were older (p<0.001) and 81% of them were hypertensive. The only respiratory parameter independently associated with the E/A ratio was mean nocturnal oxygen saturation. Seventeen patients (13%) had left ventricular hypertrophy. A multivariate analysis showed that clinic systolic blood pressure and mean nocturnal oxygen saturation were independently associated with left ventricular hypertrophy. In a logistic regression model, an age ≥58 years (OR 3.29, 95% CI 1.78–5.64) and mean nocturnal oxygen saturation <92% (OR 2.76, 95% CI 1.45–4.91) were associated with left ventricular diastolic dysfunction.Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with obstructive sleep apnoea and that it is related to the severity of oxygen desaturation.