TY - JOUR T1 - The association between resting and mild-to-moderate exercise pulmonary artery pressure JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/09031936.00019911 SP - erj00199-2011 AU - K. Whyte AU - S. Hoette AU - P. Hervé AU - D. Montani AU - X. Jaïs AU - F. Parent AU - L. Savale AU - D. Natali AU - D.S. O'Callaghan AU - G. Garcia AU - O. Sitbon AU - G. Simonneau AU - M. Humbert AU - D. Chemla Y1 - 2011/01/01 UR - http://erj.ersjournals.com/content/early/2011/07/07/09031936.00019911.abstract N2 - The mean pulmonary artery pressure (mPAP) achieved on mild-to-moderate exercise is age-related and its hemodynamic correlates remain to be documented in patients free of pulmonary hypertension (PH).Our retrospective study involved patients free of PH investigated in our centre for possible pulmonary vascular disease between 01.01.2007 and 31.10.2009, who underwent right heart catheterization at rest and during supine exercise up to 60 watts. The 38/99 patients aged <50 years were included and a mPAP of 30 mmHg was considered the upper limit of normal on exercise.The 24 subjects who developed mPAP>30 mmHg on exercise had higher resting mPAP (19±3 vs 15±4 mmHg) and indexed pulmonary vascular resistance PVRi (3.4±1.5 vs 2.2±1.1 WU.m2) (P<0.05) than the remaining 14 subjects. Resting mPAP >15 mmHg predicted exercise mPAP>30 mmHg with 88% sensitivity and 57% specificity. The 7 patients with resting mPAP 22–24 mmHg all had exercise mPAP>30 mmHg.In subjects aged <50 years investigated for possible pulmonary vascular disease and free of PH, patients with mild-to-moderate exercise mPAP>30 mmHg had higher resting PVRi and higher resting mPAP, although there was no resting mPAP threshold value that could predict normal response on mild-to-moderate exercise. The clinical relevance of such findings deserves further long-term follow-up studies. ER -