RT Journal Article
SR Electronic
T1 The association between resting and mild-to-moderate exercise pulmonary artery pressure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00199-2011
DO 10.1183/09031936.00019911
A1 K. Whyte
A1 S. Hoette
A1 P. Hervé
A1 D. Montani
A1 X. Jaïs
A1 F. Parent
A1 L. Savale
A1 D. Natali
A1 D.S. O'Callaghan
A1 G. Garcia
A1 O. Sitbon
A1 G. Simonneau
A1 M. Humbert
A1 D. Chemla
YR 2011
UL http://erj.ersjournals.com/content/early/2011/07/07/09031936.00019911.abstract
AB The mean pulmonary artery pressure (mPAP) achieved on mild-to-moderate exercise is age-related and its hemodynamic correlates remain to be documented in patients free of pulmonary hypertension (PH).Our retrospective study involved patients free of PH investigated in our centre for possible pulmonary vascular disease between 01.01.2007 and 31.10.2009, who underwent right heart catheterization at rest and during supine exercise up to 60 watts. The 38/99 patients aged <50 years were included and a mPAP of 30 mmHg was considered the upper limit of normal on exercise.The 24 subjects who developed mPAP>30 mmHg on exercise had higher resting mPAP (19±3 vs 15±4 mmHg) and indexed pulmonary vascular resistance PVRi (3.4±1.5 vs 2.2±1.1 WU.m2) (P<0.05) than the remaining 14 subjects. Resting mPAP >15 mmHg predicted exercise mPAP>30 mmHg with 88% sensitivity and 57% specificity. The 7 patients with resting mPAP 22–24 mmHg all had exercise mPAP>30 mmHg.In subjects aged <50 years investigated for possible pulmonary vascular disease and free of PH, patients with mild-to-moderate exercise mPAP>30 mmHg had higher resting PVRi and higher resting mPAP, although there was no resting mPAP threshold value that could predict normal response on mild-to-moderate exercise. The clinical relevance of such findings deserves further long-term follow-up studies.