RT Journal Article
SR Electronic
T1 Preschool asthma after bronchiolitis in infancy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00402-2011
DO 10.1183/09031936.00040211
A1 P. Koponen
A1 M. Helminen
A1 M. Paassilta
A1 T. Luukkaala
A1 M. Korppi
YR 2011
UL http://erj.ersjournals.com/content/early/2011/06/20/09031936.00040211.abstract
AB Asthma risk is lower after wheezing associated with RSV than with non-RSV infection in infancy. RSV is the main wheezing-associated virus in infants aged <6 months. We evaluated the outcome of children hospitalised for bronchiolitis at <6 months of age, with special focus on viral etiology and early risk factors.Out of 205 infants hospitalised for bronchiolitis at <6 months of age, 127 (62%) attended the control visit at age (mean) 6.5 years, and the parents of additional 39 children were interviewed by phone. Thus, follow-up data collected by identical structured questionnaires were available from 166 (81%) children. Viral etiology of bronchiolitis, studied on admission by antigen detection or polymerase chain reaction, was demonstrable in 97% of cases.Current asthma was present in 21 (12.7%) children. The figure was 8.2% in the 110 former RSV patients vs. 24% in non-RSV patients (p=0.01). The number of children with asthma ever in life was 45 (27%). In adjusted analyses, atopic dermatitis, non-RSV bronchiolitis and maternal asthma were independently significant early-life risk factors for asthma.The risk of asthma is lower after RSV bronchiolitis than after bronchiolitis caused by other viruses in children hospitalised at <6 months of age.