RT Journal Article
SR Electronic
T1 Metalloproteinases in idiopathic pulmonary fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP erj00247-2011
DO 10.1183/09031936.00024711
A1 R.C.A. Dancer
A1 A.M. Wood
A1 D.R. Thickett
YR 2011
UL http://erj.ersjournals.com/content/early/2011/06/20/09031936.00024711.abstract
AB In this review, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in the disease pathogenesis. Inhibiting metalloproteinases in IPF may therefore have therapeutic potential but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.