Rhinovirus (RV) is the most common virus and RV-C the most common RV species in paediatric intensive care respiratory admissions
- Desmond W Cox1,2,
- Siew-Kim Khoo2,3,
- Guicheng Zhang2,4,
- Katie Lindsay5,
- Anthony D Keil5,
- Geoff Knight6,
- Jim E Gern7,
- Ingrid A Laing2,3,
- Joelene Bizzintino2,3 and
- Peter N Le Souëf2
- 1Respiratory Department, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland
- 2School of Paediatrics and Child Health, University of Western Australia, WA, Australia
- 3Telethon Kids Institute, University of Western Australia, WA, Australia
- 4School of Public Health, Curtin University; Centre for Genetic Origins of Health and Disease, Curtin University and the University of Western Australia, Perth, WA, Australia
- 5Microbiology Department, PathWest Laboratory Medicine, WA
- 6Paediatric Intensive Care, Princess Margaret Hospital, Perth, WA, Australia
- 7Department of Paediatrics, University of Wisconsin-Madison, Madison, WI, USA
- Cox DW, Present address: Respiratory Department, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland. E-mail: des.cox{at}olchc.ie
Abstract
Respiratory virus infections account for a significant proportion of acute admissions to the paediatric intensive care unit (PICU). Recent studies have shown that rhinoviruses (RV) are the most frequent virus detected in severe cases of acute respiratory illnesses (ARI) admitted to a PICU. The aim of this study was to determine the prevalence of different viruses, in particular RV species, in children with ARI admitted to a tertiary PICU. Nasopharyngeal aspirates (NPA) from 229 children admitted to PICU with an ARI were analysed. RV was the most common virus detected, being present in 94 (41.0%) of samples examined, followed by respiratory syncytial virus (RSV) which was identified in 50 (21.8%) samples. A subsection analysis of cases with residual sample available of sufficient quality to allow for RV species typing showed that overall, the percentage of PICU admissions for each RV species was 22.3% for RV-C, 17.5% for RV-A and 1.7% for RV-B. This study demonstrated that RV is the most frequent virus identified in children admitted to a tertiary PICU with an ARI and RV-C is the most common RV species detected. Importantly, in the children admitted to PICU with an ARI, RV-C was by itself as common a pathogen as RSV.
Abstract
This is first report to examine the role of different RV species in ARIs in children admitted to PICU. Our study found that RV-C is the most common RV species in paediatric intensive care respiratory admissions.
Footnotes
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Conflict of interest: Ms Lindsay has nothing to disclose.
Conflict of interest: Dr. Keil has nothing to disclose.
Conflict of interest: Dr. Cox has nothing to disclose.
Conflict of interest: Dr. Knight has nothing to disclose.
Conflict of interest: Dr. Laing has nothing to disclose.
Conflict of interest: Dr. Bizzintino has nothing to disclose.
Conflict of interest: Dr. Gern has nothing to disclose.
Conflict of interest: Dr. Le Souef reports grants from National Health and Medical Research Council Australia, during the conduct of the study; .
Conflict of interest: Dr. Khoo has nothing to disclose.
Conflict of interest: Dr. Zhang has nothing to disclose.
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