Extract
Cough is the most common reason why people seek medical attention [1]. Cough hypersensitivity syndrome (CHS) is a new concept to describe a condition with long-standing hypersensitivity of vagal afferent nerves or an alteration of the central processing of their input regardless of the underlying cause [2]. The current definition of CHS is purely clinical; however a test capable of demonstrating this hypersensitivity both reliably and feasibly might be used as a diagnostic test for CHS.
Abstract
Mannitol challenge is a promising diagnostic test for cough hypersensitivity syndrome
Footnotes
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Koskela reports grants from Kuopion Hengityssäätiö, personal fees from Mundipharma Ltd, Orion Pharma Ltd, Oy, Eli Lilly Finland Ltd, Boehringer Ingelheim Finland Ltd as payments for giving scientific lectures in gatherings organized by medical companies, personal fees from Takeda Leiras Ltd and Mundipharma Ltd to visit international scientific meetings, other from owning shares of Orion Pharma Ltd worth.
Conflict of interest: Miss Lake reports other from Royal Prince Alfred Hospital, Camperdown, NSW, Australia, during the conduct of the study.
Conflict of interest: Dr. Wong reports other from Royal Prince Alfred Hospital, Camperdown, NSW, Australia, during the conduct of the study.
Conflict of interest: Dr. Brannan reports Royalty for the sale of Aridol/Osmohale, other from Stocks in Pharmaxis, outside the submitted work.
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