Extract
Thromboembolic disease is fairly common in patients with lung cancer [1–3]. This incidence seems to be higher in patients with lung adenocarcinomas [4], with approximately 15% of those with advanced-stage disease developing venous thromboembolisms (VTE) during the whole course of their disease [5–7]. Pulmonary adenocarcinomas are a heterogeneous group of diseases, that can be stratified according to the presence major oncogenic driver alterations. Anaplastic lymphoma kinase (ALK) rearrangements are detected in approximately 4% of these cases [8]. Isolated reports have suggested that patients bearing ALK-rearranged tumors might have a higher than expected incidence of thromboembolisms [9, 10]. In the present study, we have analyzed the incidence, predictors and prognostic significance of thromboembolic events in a large, multi-institutional and homogeneous cohort of advanced-stage patients with ALK-rearranged lung cancers from Spain and Portugal. Our primary objective was to estimate the incidence of thromboembolic events and their association with overall survival (OS) in these patients.
Abstract
High incidence and prognostic relevance of thromboembolic disease in patients with ALK-rearranged NSCLCs
Footnotes
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Conflict of interest: Dr. ZUGAZAGOITIA has nothing to disclose.
Conflict of interest: Dr. Biosca reports personal fees from LEO-PHARMA, personal fees from SANOFI, outside the submitted work.
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Conflict of interest: Dr. Salvador-Coloma has nothing to disclose.
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Conflict of interest: Dr. Blasco has nothing to disclose.
Conflict of interest: Dr. APARISI has nothing to disclose.
Conflict of interest: Dr. Chara has nothing to disclose.
Conflict of interest: Dr. Grau has nothing to disclose.
Conflict of interest: Dr. SOARES has nothing to disclose.
Conflict of interest: Dr. Gomez has nothing to disclose.
Conflict of interest: Dr. Zenzola has nothing to disclose.
Conflict of interest: Dr. García-Morillo has nothing to disclose.
Conflict of interest: Dr. CACHO has nothing to disclose.
Conflict of interest: Dr. DIAZ SERRANO has nothing to disclose.
Conflict of interest: Dr. AGUADO has nothing to disclose.
Conflict of interest: Dr. PONCE-AIX has nothing to disclose.
Conflict of interest: Dr. GONZALEZ-LARRIBA has nothing to disclose.
Conflict of interest: Dr. MUÑOZ has nothing to disclose.
Conflict of interest: Dr. LORA has nothing to disclose.
Conflict of interest: Dr. Paz-Ares reports other from Roche, other from Lilly, other from Bristol Meyers Squibb, other from Merck & Sharp D., other from Boehringer Ing., other from Pfizer, other from AstraZeneca, other from Amgem, other from Novartis, outside the submitted work.
Conflict of interest: Dr. MANZANO reports personal fees from PHARMAMAR, personal fees from ROCHE, personal fees from ASTRA ZENECA, outside the submitted work.
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