Extract
Allogeneic hematopoietic stem-cell transplant (alloHCT) recipients are at risk for a variety of opportunistic infections. While typical bacterial infections occur most frequently, nontuberculous mycobacteria (NTM) are becoming increasingly recognized as pathogens after alloHCT[1]. The prevalence of NTM pulmonary disease (NTM-PD) is increasing worldwide, with a rise in Ontario's period prevalence from 29.3/100,000 in 1998–2002 to 41.3/100,000 in 2006–2010[2]. Likewise, the incidence of NTM-PD post alloHCT increased from 0.11–0.23%[3, 4] in early studies to 2.7–3.15% in recent investigations[5, 6]. Despite the incidence of NTM-PD after alloHCT being far higher than in the general population[6], there are few reports addressing management and treatment outcomes of NTM-PD after alloHCT. We reviewed the experience with NTM-PD among alloHCT recipients at our institution to better characterize clinical features and treatment outcomes.
Abstract
Nontuberculous Mycobacterial Pulmonary Disease in Allogeneic Haematopoietic Stem Cell Transplant recipients
Footnotes
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Hirama has nothing to disclose.
Conflict of interest: Dr. Brode has nothing to disclose.
Conflict of interest: Dr. Beswick has nothing to disclose.
Conflict of interest: Dr. Law has nothing to disclose.
Conflict of interest: Dr. Lam has nothing to disclose.
Conflict of interest: Dr. Michelis has nothing to disclose.
Conflict of interest: Dr. Thyagu has nothing to disclose.
Conflict of interest: Dr. Viswabandya has nothing to disclose.
Conflict of interest: Dr. Lipton has nothing to disclose.
Conflict of interest: Dr. Messner has nothing to disclose.
Conflict of interest: Dr. Kim has nothing to disclose.
Conflict of interest: Dr. Marras has nothing to disclose.
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