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Haemodynamics to predict outcome in pulmonary hypertension due to left heart disease: a meta-analysis

Sergio Caravita, Céline Dewachter, Davide Soranna, Sandy Carolino D'Araujo, Amina Khaldi, Antonella Zambon, Gianfranco Parati, Antoine Bondue, Jean-Luc Vachiéry
European Respiratory Journal 2018; DOI: 10.1183/13993003.02427-2017
Sergio Caravita
Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, BelgiumDepartment of Cardiovascular, Neural and Metabolic Sciences, Ospedale S. Luca IRCCS Istituto Auxologico Italiano, Milan, Italy
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Céline Dewachter
Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium
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Davide Soranna
Department of Cardiovascular, Neural and Metabolic Sciences, Ospedale S. Luca IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Statistic and quantitative methods, University of Milano-Bicocca, Milan, Italy
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Sandy Carolino D'Araujo
Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium
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Amina Khaldi
Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium
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Antonella Zambon
Department of Cardiovascular, Neural and Metabolic Sciences, Ospedale S. Luca IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Statistic and quantitative methods, University of Milano-Bicocca, Milan, Italy
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Gianfranco Parati
Department of Cardiovascular, Neural and Metabolic Sciences, Ospedale S. Luca IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Antoine Bondue
Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium
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Jean-Luc Vachiéry
Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium
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Extract

Pulmonary hypertension (PH) is a common complication of left heart disease (LHD), as the result of a “passive” increase of left atrial pressure (LAP), leading to isolated post capillary PH [1–3]. Several haemodynamic parameters have been proposed to identify a more severe phenotype of PH-LHD, for which the increase in pulmonary artery pressure cannot be accounted for the increase in LAP, and described as combined post capillary PH with a pre-capillary component, or CpcPH [1–3]. The latter haemodynamic phenotype may potentially expose patients to a higher risk of right ventricular failure and a poorer outcome [4, 5]. However, since the last World Symposium in 2013, how to define the pre-capillary component in PH-LHD has been a matter of debate, where pathophysiological arguments have been suggested to potentially contrast with clinical and prognostic evidences [1].

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Dewachter has nothing to disclose.

Conflict of interest: Dr. Soranna has nothing to disclose.

Conflict of interest: Sandy Carolino D'Araujo

Conflict of interest: Dr. Khaldi has nothing to disclose.

Conflict of interest: Dr. Zambon has nothing to disclose.

Conflict of interest: Dr. Parati has nothing to disclose.

Conflict of interest: Dr. Bondue has nothing to disclose.

Conflict of interest: Dr. Vachiéry reports grants from Actelion, outside the submitted work.

Conflict of interest: Dr. Carolino D'Araujo has nothing to disclose.

Conflict of interest: Dr. Caravita reports grants from Actelion, outside the submitted work.

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Haemodynamics to predict outcome in pulmonary hypertension due to left heart disease: a meta-analysis
Sergio Caravita, Céline Dewachter, Davide Soranna, Sandy Carolino D'Araujo, Amina Khaldi, Antonella Zambon, Gianfranco Parati, Antoine Bondue, Jean-Luc Vachiéry
European Respiratory Journal Jan 2018, 1702427; DOI: 10.1183/13993003.02427-2017

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Haemodynamics to predict outcome in pulmonary hypertension due to left heart disease: a meta-analysis
Sergio Caravita, Céline Dewachter, Davide Soranna, Sandy Carolino D'Araujo, Amina Khaldi, Antonella Zambon, Gianfranco Parati, Antoine Bondue, Jean-Luc Vachiéry
European Respiratory Journal Jan 2018, 1702427; DOI: 10.1183/13993003.02427-2017
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