Several studies from Southern Africa report a high risk of tuberculosis (TB) among individuals who have previously been treated for the disease compared to those never before treated [1–5]. In high-burden settings, recurrent TB may affect large numbers of individuals even after successful treatment, with exogenous reinfection as an important underlying mechanism [2–4]. For example, in Cape Town, South Africa, a city with a high incidence of TB, previously treated individuals constitute one-third of the burden of notified TB .
High TB prevalence in previously treated people suggests potential for targeted interventions in high-burden settings http://ow.ly/ihG83015s4l
We would like to thank the ZAMSTAR study team, in particular, Ab Schaap (London School of Hygiene and Tropical Medicine, London, UK), Rory Dunbar (Stellenbosch University, Tygerberg, South Africa) and those involved in the prevalence surveys. We are grateful to those who agreed to participate in the surveys. We thank the City of Cape Town Health Dept, and the Provincial and National Tuberculosis Programs of South Africa and Zambia for their support.
Support statement: This work was supported by the German Research Foundation (DFG) through a scholarship grant (MA 5483/2-1) to F.M. Marx and a grant provided by the National Institutes of Health (R01 AI112438-01) to T. Cohen. The ZAMSTAR study was supported by a subcontract from Johns Hopkins University with funds provided by a grant from the Bill and Melinda Gates Foundation (19790.01). The contents of this study are solely the responsibility of the authors and do not necessarily represent the official views of the funders. Funding information for this article has been deposited with the Open Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received January 15, 2016.
- Accepted May 24, 2016.
- Copyright ©ERS 2016