Study 1237.5 common study baseline | 1.158±0.010 | | 1.161±0.010 | |
Tiotropium+olodaterol 5/5 µg | | | | |
versus olodaterol 5 µg | 0.123±0.012 (0.100–0.146) | <0.0001 | 0.082±0.012 (0.059–0.106) | <0.0001 |
versus tiotropium 5 µg | 0.117±0.012 (0.094–0.140) | <0.0001 | 0.071±0.012 (0.047–0.094) | <0.0001 |
Tiotropium+olodaterol 2.5/5 µg | | | | |
versus olodaterol 5 µg | 0.109±0.012 (0.086–0.132) | <0.0001 | 0.058±0.012 (0.034–0.081) | <0.0001 |
versus tiotropium 2.5 µg | 0.093±0.012 (0.070–0.116) | <0.0001 | 0.029±0.012 (0.005–0.052) | 0.0174 |
versus tiotropium 5 µg | 0.102±0.012 (0.080–0.125) | <0.0001 | 0.046±0.012 (0.023–0.070) | 0.0001 |
Tiotropium+olodaterol 5/5 µg | | | | |
versus tiotropium+olodaterol 2.5/5 µg | 0.014±0.012 (-0.008–0.037) | 0.2169 | 0.024±0.012 (0.001–0.048) | 0.0407 |
Study 1237.6 common study baseline | 1.150±0.010 | | 1.150±0.010 | |
Tiotropium+olodaterol 5/5 µg | | | | |
versus olodaterol 5 µg | 0.132±0.013 (0.108–0.157) | <0.0001 | 0.088±0.013 (0.063–0.113) | <0.0001 |
versus tiotropium 5 µg | 0.103±0.012 (0.078–0.127) | <0.0001 | 0.050±0.013 (0.024–0.075) | 0.0001 |
Tiotropium+olodaterol 2.5/5 µg | | | | |
versus olodaterol 5 µg | 0.121±0.012 (0.096–0.145) | <0.0001 | 0.067±0.013 (0.042–0.092) | <0.0001 |
versus tiotropium 2.5 µg | 0.131±0.012 (0.106–0.155) | <0.0001 | 0.062±0.013 (0.037–0.087) | <0.0001 |
versus tiotropium 5 µg | 0.091±0.012 (0.066–0.115) | <0.0001 | 0.029±0.013 (0.004–0.054) | 0.0231 |
Tiotropium+olodaterol 5/5 µg | | | | |
versus tiotropium+olodaterol 2.5/5 µg | 0.012±0.012 (-0.013–0.036) | 0.3394 | 0.021±0.013 (-0.004–0.046) | 0.1073 |