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Metalloproteinases in idiopathic pulmonary fibrosis

R.C.A. Dancer, A.M. Wood, D.R. Thickett
European Respiratory Journal 2011; DOI: 10.1183/09031936.00024711
R.C.A. Dancer
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Abstract

In this review, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in the disease pathogenesis. Inhibiting metalloproteinases in IPF may therefore have therapeutic potential but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.

  • Idiopathic pulmonary fibrosis matrix metalloproteinase.
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Vol 51 Issue 4 Table of Contents
European Respiratory Journal: 51 (4)
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Metalloproteinases in idiopathic pulmonary fibrosis
R.C.A. Dancer, A.M. Wood, D.R. Thickett
European Respiratory Journal Jan 2011, erj00247-2011; DOI: 10.1183/09031936.00024711

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Metalloproteinases in idiopathic pulmonary fibrosis
R.C.A. Dancer, A.M. Wood, D.R. Thickett
European Respiratory Journal Jan 2011, erj00247-2011; DOI: 10.1183/09031936.00024711
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