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Supplementation with vitamin A early in life and subsequent risk of asthma

W. Checkley, K.P. West Jr, R.A. Wise, L. Wu, S.C. LeClerq, S. Khatry, J. Katz, P. Christian, J.M. Tielsch, A. Sommer
European Respiratory Journal 2011; DOI: 10.1183/09031936.00006911
W. Checkley
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K.P. West
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R.A. Wise
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L. Wu
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S.C. LeClerq
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S. Khatry
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J. Katz
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P. Christian
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J.M. Tielsch
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A. Sommer
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Abstract

Animal models suggest that vitamin A deficiency affects lung development adversely and promotes airway hyper-responsiveness, and may predispose to an increased risk of asthma. We examined the long-term effects of vitamin A supplementation early in life on later asthma risk.

In 2006–2008, we revisited participants from two cohorts in rural Nepal enrolled in randomized trials of vitamin A supplementation. The first cohort received vitamin A or placebo for <16 months during their pre-school years (1989–1991). The second cohort was born to mothers who received vitamin A, beta-carotene or placebo before, during and after pregnancy (1994–1997). At follow-up, we asked about asthma symptoms and performed spirometry.

Of 6421 eligible to participate, 5430 (85%) responded to our respiratory survey. Wheezing prevalence during the past year was 4.8% in participants aged 9–13 years and 6.6% in participants aged 14–23 years. We found no differences between the vitamin A supplemented versus placebo groups from either trial in the prevalences of lifetime or current asthma and wheeze or in spirometric indices of obstruction (p≥0.12 for all comparisons).

Vitamin A supplementation early in life was not associated with a decreased risk of asthma in an area with chronic vitamin A deficiency.

  • Asthma
  • longitudinal study
  • randomized clinical trial
  • vitamin A
  • ERS
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Supplementation with vitamin A early in life and subsequent risk of asthma
W. Checkley, K.P. West, R.A. Wise, L. Wu, S.C. LeClerq, S. Khatry, J. Katz, P. Christian, J.M. Tielsch, A. Sommer
European Respiratory Journal Jan 2011, erj00069-2011; DOI: 10.1183/09031936.00006911

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Supplementation with vitamin A early in life and subsequent risk of asthma
W. Checkley, K.P. West, R.A. Wise, L. Wu, S.C. LeClerq, S. Khatry, J. Katz, P. Christian, J.M. Tielsch, A. Sommer
European Respiratory Journal Jan 2011, erj00069-2011; DOI: 10.1183/09031936.00006911
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