Abstract
High-resolution computed tomography (HRCT) may be useful to monitor lung disease in children with common variable immunodeficiency disorders (CVID). We evaluated interobserver agreement and correlation with pulmonary function tests (PFTs) for automated quantification and visual scoring of air trapping and airway wall thickening on HRCT in paediatric CVID-patients.
In a cohort of 51 children with CVID, HRCT was analysed visually and automated for presence of air trapping and airway wall thickening. PFTs were expressed as percent predicted. Disease duration, physician-diagnosed pneumonias and antibiotics prophylaxis were recorded.
Interobserver agreement for automated airway wall thickening was good with an intra-class correlation coefficient of 0.88, compared to 0.51 for visual scoring. Presence of air trapping on HRCT correlated significantly with PFTs and disease duration, but was not associated with previous pneumonias. Airway wall thickening did not correlate significantly with PFTs or disease duration and was not associated with previous pneumonias or prophylactic antibiotics use.
In children with CVID disorders HRCT air trapping measurements are significantly correlated with PFTs and disease duration. Quantitative air trapping is a feasible and promising technique for small airways disease quantification that may be applied to monitor (silent) disease progression in CVID.
- ERS