Abstract
Background: Osteopontin (OPN) is a phosphorylated acidic glycoprotein firstly was related to cell growth, differentiation in malignancy process. Now it seems that OPN paly major role in cell recruitment and regulation of inflammation. Also found to be associated with elevated mediators, cellularity and Th1cytokines expression at inflammation sites.
Purpose of study: to compare OPN plasma level between community acquired pneumonia (CAP) and control healthy subjects. Also to correlate between OPN and disease severity.
Methods: Study was conducted on 2groups, Group I: included 25 CAP patients. Group II: included 15 age-matched healthy control subjects admitted in Chest Department, Tanta University Hospitals. OPN levels were measured in serum by (ELISA). CURB-65 score, hospitalization length and CRP were used to detect severity in CAP patients on hospitalization.
Results: Mean value of serum OPN in group I was (78.42 ± 8.7) ng/ml while in group II was (19.43 ± 8.3) ng/ml. OPN was significantly higher in patients with CAP compared to controls (p=0.001). Also, significantly higher levels of CRP, total WBCs and neutrophils was detected in CAP than control subjects (p < 0.001). There was significant positive correlation between plasma level of OPN, and severity of CAP based on CURB-65 (r = 0.352, p < 0.001), length of hospitalization (r = 0.231, p= < 0.001) and CRP (r = 0.341, p<0.001).
Conclusion: plasma OPN increased markedly in patients with CAP compared to control, also it was significantly correlated with severity of disease. These findings suggest that OPN can be considered as novel additional marker for both diagnostic and prognostic purpose in CAP development moreover in severity assessment.
- Copyright ©the authors 2017