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Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis

Thomas Gille, Morgane Didier, Marouane Boubaya, Loris Moya, Angela Sutton, Zohra Carton, Fanny Baran-Marszak, Danielle Sadoun-Danino, Dominique Israël-Biet, Vincent Cottin, Frederic Gagnadoux, Bruno Crestani, Marie-Pia d'Ortho, Pierre-Yves Brillet, Dominique Valeyre, Hilario Nunes, Carole Planès
European Respiratory Journal 2017 49: 1601934; DOI: 10.1183/13993003.01934-2016
Thomas Gille
Dept of Physiology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, FranceLaboratory EA2363, University Paris 13, Sorbonne Paris Cité, Bobigny, France
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Morgane Didier
Pulmonary Dept, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Marouane Boubaya
Dept of Clinical Research, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Loris Moya
Dept of Radiology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Angela Sutton
Biochemistry Laboratory, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, FranceINSERM 1148, University Paris 13, Sorbonne Paris Cité, Bobigny, France
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Zohra Carton
Pulmonary Dept, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Fanny Baran-Marszak
Laboratory of Biological Hematology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, FranceINSERM 978, University Paris 13, Sorbonne Paris Cité, Bobigny, France
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Danielle Sadoun-Danino
Pulmonary Dept, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Dominique Israël-Biet
Pulmonary Dept, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, FranceUniversity Paris Descartes, Sorbonne Paris Cité, Paris, France
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Vincent Cottin
National Reference Centre for Rare Pulmonary Diseases, Dept of Respiratory Medicine, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, FranceUniversité Claude Bernard Lyon 1, Lyon, France
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  • ORCID record for Vincent Cottin
Frederic Gagnadoux
INSERM 1063, Université Bretagne Loire (UBL), Angers, FrancePulmonary Dept, Angers University Hospital, Angers, France
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Bruno Crestani
Dept of Pneumology A, Bichat Hospital, Assistance Publique-Hôpitaux de Paris, Paris, FranceDHU FIRE, University Paris Diderot, Sorbonne Paris Cité, Paris, France
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Marie-Pia d'Ortho
DHU FIRE, University Paris Diderot, Sorbonne Paris Cité, Paris, FranceDept of Physiology, Bichat Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
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Pierre-Yves Brillet
Laboratory EA2363, University Paris 13, Sorbonne Paris Cité, Bobigny, FranceDept of Radiology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Dominique Valeyre
Laboratory EA2363, University Paris 13, Sorbonne Paris Cité, Bobigny, FrancePulmonary Dept, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Hilario Nunes
Laboratory EA2363, University Paris 13, Sorbonne Paris Cité, Bobigny, FrancePulmonary Dept, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France
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Carole Planès
Dept of Physiology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, FranceLaboratory EA2363, University Paris 13, Sorbonne Paris Cité, Bobigny, France
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  • For correspondence: carole.planes@aphp.fr
A full list of the collaborators and their affiliations can be found in the Acknowledgements section
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Abstract

The objectives of this prospective study were: 1) to determine the prevalence and determinants of obstructive sleep apnoea (OSA) in patients with newly diagnosed idiopathic pulmonary fibrosis (IPF); 2) to determine whether OSA was associated with cardiovascular disease (CVD) as well as increased oxidative stress and levels of IPF biomarkers in the blood.

A group of 45 patients with newly diagnosed IPF attended polysomnography. The prevalence of CVD and the severity of coronary artery calcification were investigated by high-resolution computed tomography. The levels of 8-hydroxydeoxyguanosine (8-OH-DG) and various IPF biomarkers in the blood were compared between patients with no or mild OSA (apnoea–hypopnoea index (AHI) <15 events·h−1), with moderate OSA (15 ≤AHI <30 events·h−1) and with severe OSA (AHI ≥30 events·h−1).

The prevalence of moderate-to-severe OSA and severe OSA was 62% and 40%, respectively. AHI did not correlate with demographic or physiological data. All patients with severe OSA had a medical history of CVD, versus 41.2% and 40% of those with no or mild OSA, or with moderate OSA, respectively (p<0.0001). Ischaemic heart disease (IHD) and moderate-to-severe coronary artery calcifications were strongly associated with severe OSA. The 8-OH-DG and matrix metalloproteinase-7 serum levels were significantly increased in the severe OSA group.

Moderate-to-severe OSA is highly prevalent in incident IPF and severe OSA is strongly associated with the presence of CVD, particularly IHD.

Abstract

Severe sleep apnoea syndrome is associated with cardiovascular disease in incident idiopathic pulmonary fibrosis http://ow.ly/9GTv30bgIOR

Footnotes

  • This article has supplementary material available from erj.ersjournals.com

  • Support statement: This work was supported by the Chancellerie des Universités de Paris-Fondation du Legs Poix (grant: 637), the Programme Hospitalier de Recherche Clinique (PHRC) (grant: AOR 07076) and the University Paris 13/ComUE Sorbonne Paris Cité (grant: FPI-SPC). Funding information for this article has been deposited with the Crossref Funder Registry.

  • Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com

  • Received October 3, 2016.
  • Accepted February 28, 2017.
  • Copyright ©ERS 2017
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Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis
Thomas Gille, Morgane Didier, Marouane Boubaya, Loris Moya, Angela Sutton, Zohra Carton, Fanny Baran-Marszak, Danielle Sadoun-Danino, Dominique Israël-Biet, Vincent Cottin, Frederic Gagnadoux, Bruno Crestani, Marie-Pia d'Ortho, Pierre-Yves Brillet, Dominique Valeyre, Hilario Nunes, Carole Planès, collaborators
European Respiratory Journal Jun 2017, 49 (6) 1601934; DOI: 10.1183/13993003.01934-2016

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Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis
Thomas Gille, Morgane Didier, Marouane Boubaya, Loris Moya, Angela Sutton, Zohra Carton, Fanny Baran-Marszak, Danielle Sadoun-Danino, Dominique Israël-Biet, Vincent Cottin, Frederic Gagnadoux, Bruno Crestani, Marie-Pia d'Ortho, Pierre-Yves Brillet, Dominique Valeyre, Hilario Nunes, Carole Planès, collaborators
European Respiratory Journal Jun 2017, 49 (6) 1601934; DOI: 10.1183/13993003.01934-2016
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