Sleep disordered breathing (SDB) is common in patients with coronary disease, but its impact on post-operative recovery after coronary artery bypass graft surgery (CABG) is unclear. We therefore determined the effects of SDB on post-operative outcome after elective CABG.
In this prospective two-centre study, 219 patients due to receive elective CABG underwent cardiorespiratory polygraphy for SDB prior to surgery and were monitored for post-operative complications. The primary end-point was a composite of 30-day mortality or major post-operative complications (cardiac, respiratory, surgical, infectious, acute renal failure or stroke). Key secondary end-points were single components of the primary end-point.
SDB was present in 69% and moderate/severe SDB in 43% of the CABG patients. There was no difference in the composite of 30-day mortality or major postoperative complications between patients with and without SDB (OR 0.97, 95% CI 0.49–1.96) and between patients with moderate/severe SDB and no/mild SDB (OR 1.07, 95% CI 0.55–2.06). However, moderate/severe SDB was associated with higher rates of mortality (crude OR 10.1, 95% CI 1.22–83.5), sepsis (OR 2.96, 95% CI 1.17–7.50) and respiratory complications (OR 2.85, 95% CI 1.46–5.55).
Although SDB was not associated with higher overall morbidity/mortality, moderate/severe SDB may increase the risk of death, and septic and respiratory complications, after elective CABG.
Sleep disordered breathing increases the rate of life-threatening post-operative complications after coronary surgery http://ow.ly/Ue25307U90Q
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This study is registered in the German Clinical Trial Register with identifier number DRKS00000704.
Support statement: The study was supported by the Federal Ministry of Education and Research (BMBF), Germany (FKZ: 01EO1002). Funding information for this article has been deposited with the Open Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received July 26, 2016.
- Accepted December 16, 2016.
- Copyright ©ERS 2017