Chronic obstructive pulmonary disease (COPD) is a systemic disorder with significant pulmonary and extrapulmonary manifestations . The right and left heart and the great vessels may be affected . Specifically, patients with COPD (especially those with hypoxaemia) have functional alterations in cardiac autonomic modulation, manifested by tachycardia at rest, reduced baroreflex sensitivity, reduced heart rate variability and abnormal recovery of heart rate following exercise .
COPD patients establish a flat shortening of QT interval during maximum exercise, irrespectively of medication taken http://ow.ly/XMrb308wUZt
Support statement: A.K. Boutou was a recipient of an ERS Short Term Research Fellowship when the study was conducted.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received December 6, 2016.
- Accepted December 17, 2016.
- Copyright ©ERS 2017