Obstructive sleep apnoea (OSA) is a very prevalent disorder with well proven mid- and long-term deleterious consequences, such as increased risk of cardiovascular, metabolic and neurocognitive diseases . Recently, considerable data from both animal models and patient studies also suggest that OSA increases the risk of cancer incidence and mortality . Some of these studies indicate that nocturnal hypoxic events experienced by OSA patients as a consequence of recurrent upper airway obstructions may be a main challenge driving tumour progression [3, 4]. Although the clinical and experimental data available do not undoubtedly prove a relationship between cancer and OSA , its plausibility has raised the interest of basic and clinical researchers in the field, warranting further investigation .
Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice http://ow.ly/BoF6306AnI0
The authors thank Ana Gordillo (Universidad de Valladolid/CIBERES, Valladolid, Spain) for her technical support.
Support statement: CIBER de Enfermedades Respiratorias (CB06/06/0050); Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, MINECO/FEDER, UE (BFU2015-70616-R, PI2014-00004); and Spanish Association Against Cancer (APRO-I Valladolid). Funding information for this article has been deposited with the Open Funder Registry.
Conflict of interest: None declared.
- Received October 28, 2016.
- Accepted November 19, 2016.
- Copyright ©ERS 2017