We thank S. Dimopoulos and co-workers for their particular interest in our study  and their contributions to this issue. The peripheral muscle hypothesis in pulmonary arterial hypertension (PAH)  is certainly of great and growing interest due to the potential of muscle function as a target for meaningful intervention. Accordingly, our study explored the value of quadriceps muscle oxygenation profiles in patients with PAH by means of near-infrared spectroscopy (NIRS) . The satisfactory correlation between vastus lateralis muscle tissue oxygenation index (StO2) and mixed venous oxygen saturation (SvO2) both at rest and during exercise support the use of NIRS in the noninvasive investigation of patients with PAH. Importantly, they suggest that skeletal muscle oxygenation profiles reflect the pathophysiology of PAH.
Near-infrared spectroscopy offers a qualitative, noninvasive indication of mixed venous oxygen saturation in PAH http://ow.ly/MctV306eEYC
Support statement: Marios Panagiotou is the recipient of an ERS PAH Long-Term Research Fellowship, number 2014-3106, supported by an unrestricted grant from GSK. Funding information for this article has been deposited with the Open Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received November 3, 2016.
- Accepted November 9, 2016.
- Copyright ©ERS 2017