Asthma is a chronic airway disease with a heterogeneous clinical presentation , and a subset of ∼5–10% of patients suffer from severe disease . Chronic obstructive pulmonary disease (COPD) is different from asthma with respect to underlying pathobiology but shares some clinical features with severe asthma, for instance fixed airway obstruction and small airway dysfunction [3, 4]. In COPD, the consequences of the disease for physical activity in daily life have been studied intensively [5–7]; in contrast, only few data are available on patients with asthma . Measurements of physical activity in adult patients with stable asthma of different severity grades are lacking, and associations with airway physiology have not been evaluated.
Physical activity is reduced in severe asthma; impulse oscillometry was a better predictor than spirometry http://ow.ly/6WdN305D9aV
We thank Regine Wieland, Petra Hundack-Winter, Margret Gleiniger, Zaklina Hinz, Susann Prange, Corinna Derwort (LungClinic Grosshansdorf, Grosshansdorf, Germany), Christine Ballhausen, Johanna Döhling, Andrea Glaewe, Edda Horst, Lenka Krabbe, Birgit Kullmann, Monika Rennhack and Eva Wittmer (Research Center Borstel, Borstel, Germany) for their excellent support in study logistics.
The members of the ERA Study Group are as follows: Thomas Bahmer, Benjamin Waschki and Klaus F. Rabe (LungClinic Grosshansdorf, Pulmonology, Grosshansdorf, Germany), Anne-Marie Kirsten, Frauke Pedersen and Henrik Watz (Pulmonary Research Institute at LungClinic Grosshansdorf), Christian Herzmann and Annika Opitz (Center for Clinical Studies, Research Center Borstel, Borstel, Germany), Peter Zabel (Medical Clinic, Research Center Borstel) and Karoline I. Gaede (Biobank, Research Center Borstel).
The authors' contributions are as follows. Conception and design of the study: T. Bahmer, B. Waschki, P. Zabel, A-M. Kirsten, K.F. Rabe, H. Watz; acquisition, analysis and interpretation: T. Bahmer, B. Waschki, F. Schatz, C. Herzmann, A-M. Kirsten, H. Watz; drafting the manuscript: T. Bahmer, B. Waschki, F. Schatz, H. Watz; critically revising the manuscript: C. Herzmann, P. Zabel, A-M. Kirsten, K.F. Rabe. All authors read and approved the final version of the manuscript.
Support statement: This study has been supported by the German Center for Lung Research (DZL) which is funded by governmental grants. Funding information for this article has been deposited with the Open Funder registry.
Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com
- Received July 14, 2016.
- Accepted October 18, 2016.
- Copyright ©ERS 2017