Abstract
Background: We intended to investigate whether smoking and COPD is the independent risk factor of osteoporosis in male smoker in our population.
Aims and Objectives: To see the frequency of osteoporosis in male smokers with and without COPD.
Methods: This cross sectional comparative study was carried out in Sylhet Medical College Hospital, Bangladesh, during 01/07/2013 to 30/06/2015. 74 male smokers with COPD and 66 age-matched male smokers without COPD (control group) were consecutively enrolled. All individuals were underwent BMD by DEXA.
Results: T-score (-2.31 ± 0.92 versus -1.65 ± 0.93; p<0.001) and BMD (0.77 ± 0.11 gm/Cm2 versus 0.86 ± 0.12 gm/Cm2; p<0.001) of the neck of femur were significantly lower in COPD group than that of control group (0.77 ± 0.11 gm/Cm2 versus 0.86 ± 0.12 gm/Cm2; p<0.001) .
BMD | COPD (n=74) | Control (n=66) | p value |
T score | -2.31 ± 0.92 | -1.65 ± 0.93 | *p<0.001 |
Normal | 6 (8.1) | 18 (27.3) | †p<0.05 |
Osteopenia | 32 (43.2) | 37 (56.1) | †p<0.05 |
Osteoporosis | 36 (48.6) | 11 (16.7) | †p<0.05 |
BMD (gm/Cm2) | 0.77 ± 0.11 | 0.86 ± 0.12 | †p<0.05 |
*Unpaired t test and †Z test
Similarly T-score (-3.01 ± 1.26 in COPD versus -1.92 ± 1.13; p<0.001) and BMD of the lumbar spine (0.86 ± 0.16 gm/Cm2 versus 0.97 ± 0.13 gm/Cm2; p<0.001) were significantly lower in COPD group than that of control group. Multivariate analysis showed that presence of COPD significantly predicts osteoporosis (OR=3.508; 95% CI 1.511-8.142; p=0.003). But age, smoking-pack years and BMI did not have significant association with osteoporosis.
Conclusions: The prevalence of osteoporosis in patients with COPD was higher than the age-matched control subjects without COPD. A lower FEV1 further increases the risk of osteoporosis in patients with COPD.
- Copyright ©the authors 2016