Abstract
PCD patients may be prone to sleep disordered breathing (SDB), due to upper and lower airway disease. We hypothesized that SDB would be associated with more severe PCD, and aimed to determine whether particular subgroups would be at higher risk.
We investigated 84 children with confirmed PCD (48 girls, age 10.1 ± 4.4 years) for SDB and PCD severity. Patients underwent overnight attended polysomnography (n=62) or polygraphy (n=22) self-ventilating in room air, HRCT, spirometry, and lung clearance index (LCI).
Results are summarized in Table 1. Whilst the majority of patients had flow limitation on the nasal pressure transducer, suggestive of increased upper airways resistance, only 1 patient had evidence of mild OSA with an obstructive apnoea-hypopnoea-index (OAHI) of 2/ hours total sleep time (hTST). 23 patients (27%) had a mildly raised AHI (1.5 [1.1-2.1], median [IQR]) / hTST mainly due to central apnoeas. Transcutaneous CO2 was normal in all. 7 had mean SpO2<95%. Patients with lower baseline saturations and higher oxygen desaturation index (ODI) had more lobes affected with bronchiectasis. There was no association between sleep parameters and spirometry or LCI. Sleep architecture was normal.
In summary, we found only mild SDB in children with PCD. We could not delineate a high risk group for SDB based on parameters of lung disease. We conclude that routine screening for SDB is not indicated in children with PCD.
- Copyright ©the authors 2016