Abstract
Procalcitonin (PCT) and C-reactiveprotein ( C-RP) are widely used to estimate the severity of inflammation in patients (pts.) with CAP. However, there is no data on the level of these markers in pregnant with CAP on the background of antibiotic therapy (ABT).
Aim: to study changes in levels of inflammatory markers (PCT, C-RP) in pregnant with CAP.
Materials and methods: we studied levels of PCT and C-RP in two groups of pts. Group 1 – 45 pregnant with CAP (age (M ± m) 28,4 ± 1,0 yrs., at term 28,5 ± 0,9 wks.), before antibiotic prescription (visit 1) and on the 5th day of therapy (visit 2). Group 2 – 15 healthy pregnant (age 31,1 ± 2,2 yrs, at term 33,7 ± 1,2 wks). All pts. from group 1 admitted diagnostic criteria for CAP and had significant clinical improvement by the fifth day of treatment. Table 1 shows the results of comparison of the studied markers between groups and visits.
Visit 1 | Visit 2 | |||
Group | PCT Me [25–75%] ng/ml | C-RP Me [25–75%] mg/l | PCT Me [25–75%] ng/ml | C-RP Me [25–75%] mg/l |
1 | 0,17 [0,12–0,20]∗◊ | 32 [18–65]∗◊ | 0,05 [0,04–0,09]∧ | 6 [4–12]∨ |
2 | 0,047 [0,025–0,10] | 2,05 [1,8–2,9] |
∗- p = 0,000 between visits by Wilcoxon; ◊- p = 0,000 with group 2 by Mann-Whitney;∧ - p = 0,3 with group 2 by Mann-Whitney; ∨ - 0,000 with group 2 by Mann-Whitney
Conclusions: in pregnant with CAP, on the 5th day of ABT levels of PCT, unlike C-RP, decreased to the numbers comparable with healthy pregnant.
- Copyright ©the authors 2016