Abstract
Purpose: To investigate the capability of 3D-dynamic oxygen-enhanced MR (OE-MR) and Computed tomography (CT) in patients with Cystic Fibrosis (CF) and pulmonary function tests (PFT).
Materials/Methods: 13 patients (median age: 28, female n=7) with a range of CF lung disease underwent OE-MR (1.5 T MR scanner). Coronal T1 parameter maps were obtained during free breathing. 3D coronal volumes of both lungs were acquired while patients alternately breathed room air and 100% oxygen. Images were fitted pixel by pixel. T1-parameter maps were generated and the following OE-MR parameters were measured: maximum O2-uptake(dPO2), wash-in and wash-out time. CT and PFT were available. Brody score was assessed by two radiologists. Total CT Brody score (CF-CT) was compared with PFT (%FEV1) and the OE-MR parameters using Pearson correlation.
Results: Intraclass correlation for CF-CT(range:2-53,median 32) was high (0.86). dPO2, wash-in and wash-out time showed a significant correlation with CF-CT (dPo2:r=-0.691;p=0.009; wash-in/wash out:r=0.712;p=0.006). There was a significant correlation between dPO2, wash-in time and %FEV1 (O2-uptake: r=0.85;p<0.001; wash-in: r=-0.86;p<0.001).
Conclusion: Functional lung imaging using OE-MR has the capability to assess the severity of CF lung disease showing a significant correlation with %FEV1 and CT Brody score. For long-term CF care, avoidance of cumulative radiation burden is desirable and feasible using OE-MR.
- Copyright ©the authors 2016