Abstract
Our aim was to study the effects of eucalyptol (EUC) against short and long-term cigarette smoke exposure in C57BL6 mice. Ethics committee (UFRJ-DFBCICB046). Male mice are grouped in CS or sham-smoked. CS groups are exposed during five days (acute phase) or sixty days (chronic phase) and treated with EUC (1, 3 or 10 mg/mL by inhalation route). EUC was given during CS in acute study; however, EUC was given during 60 days after emphysema condition in chronic study. In acute phase EUC reduced leukocyte numbers (EUC 3 and 10), TNF-α (EUC 10 mg/mL), IL-1β (EUC 3 and 10), KC (EUC 10) and IL-6 (EUC 10) when compared to CS group. ROS and MDA levels were reduced in EUC3 and EUC 10 when compared to CS group. Finally, all doses of EUC reduced NFκB expression in comparison to CS group. In chronic phase EUC improve histology of alveolar septa and reduced leukocytes in alveoli when compared to CS group. TNF-α, IL-1β, KC and IL-6 levels were lower in EUC 10 as well as MDA levels also were lower in EUC 10. We suggest that eucalyptol has anti-inflammatory and antioxidant effects on mouse lungs, at least for CS condition.
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