Abstract
Research: to study interrelation of clinical and functional parametres, level of markers of system inflammation, arterial rigidity at patient with COPD and at a combination COPD and coronary heart disease. Study of external respiration function was done with whole-body plethysmography, functional parameters of the right departments of the heart was done with echocardiography. We estimated parametres of rigidity of an aorta by means of an indirect arteriography. Measurements of TNF-α, Il-6, Il-8, sCD31 levels in the peripheral blood were performed with ELISA. Detection of CD38+ lymphocytes in the peripheral blood was done with immunofluorescence. 50 patients were examed in the period of exacerbation and after 12 month of observation. The 1st group included 30 patients with severe and very severe COPD, the 2nd group - 20 patients with severe and very severe COPD in combination with coronary heart disease. The control group was made by 20 non-smoking healthy persons. In both groups independently of the period of observation we found violation mechanical properties of aorta that manifested as the increase of pulse wave velocity in aorta (PWVao). But Aix brachial changed at patients of the 1st group more significantly. Both groups in the period of exacerbation and after 12 months marked the increase of expression of CD38 on peripheral blood lymphocytes and sCD31 – marker of endothelial dysfunction. In the groups we found the increase of the level of Il-8 independently of the period of observation that shows persisting systemic inflammation. The informative marker reflexing the phase of disease is TNF-α. Results confirm the presence of endothelial dysfunction and remodeling of vessels at patients with COPD.
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