Abstract
We aimed to investigate effect of long term noninvasive mechanical ventilation(NMV) after dicharge on right heart function and hemodynamic results in hospitalized patients in intensive care unit(ICU) with respiratory failure due to obesity hypoventilation syndrome(OHS)
Methods:Level of brain natriuretic peptide(BNP) at admission and after 9th month of discharge,hemodynamic and echocardiographic parameters of patients were recorded prospectively in level III ICU. Data were compared.
Results: 36 OHS patients (23 female) with mean body mass index 45±11,age 61±13 were enrolled in the study.During 9 month among echocardiographic parameters related with right heart function significant change were found in systolic pulmonary arterial pressure,TAPSE and serum BNP levels(43±8 vs 38±8 mmhg ,p‹0.002; 2.1±0.3 cm vs 2.4±0.4 cm,p‹0.002; 1049±624 vs 358±255 pg/ml, p=0.029 respectively).However there was no significant difference in left ventricle ejection fraction and left atrial function(63 ±7 vs 64 ±7 %, p>0.11 ;3.7± 0.7 vs 3.6± 0.6 p>0.55 respectively)
Conlusion: Long term NIV treatment in patients with respiratory failure due to OHS provides significant improvement in right heart failure and BNP level.
- Non-invasive ventilation - acute respiratory failure
- Intensive care
- Non-invasive ventilation - long-term
- © 2014 ERS