Abstract
Introduction: Sepsis is an important cause of mortality on patients with pulmonary arterial hypertension (PAH). The presence of inflammation is well established in sepsis and it is possible that the association of these two conditions could increase the impedance of respiratory system.
Objectives: To determine the effects of sepsis in respiratory mechanics in a monocrotaline PAH rat model.
Methods: We studied the respiratory mechanical propertiesof 24 rats divided in three groups: control (CTRL), monocrotaline induced PAH (PAH) and monocrotaline induced PAH with cecal ligation and puncture induced sepsis (PAHs). Results: Pressure dissipation against the viscoelastic components (ΔP2,rs) was increased in PAHs compared with CTRL(ΔP2,rs PAHs= 1.97±0.48; ΔP2,rs CTRL= 1.29±0.54, p= 0.34), but not with PAH(ΔP2,rs PAH= 1,54±0.18, p= 0.2). There is no difference in respiratory system elastance (E,rs) between the groups, but the lung elastance (E, L) of PAHs was elevated comparing to CTRL group(E,L PAHs=3.1±0.65; E,L CTRL=2.38±0.61, p=0.47). Respiratory system resistance (R,rs) was superior in CTRL comparing to PAHs and PAH (R,rs CTRL=0.18±0.7; R,rs PAHs=0.11±0.04, p= 0.01; R,rs PAH=0.12±0.02, p=0.05 ).
Conclusion: Sepsis does not increase elastic and resistive properties of respiratory system in a monocrotaline induced PAH.
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