Abstract
Background : The monitoring of evolution in patients with Idiopathic Pulmonary Arterial Hypertension (IPAH) in the context of therapeutic arsenal development more widely and promising is very important, alongside the identification of new prognosis indicators.
Objective: Evaluation the effort tolerance and body composition in IPAH patients and corelation with other prognosis factors.
Methods: The adult IPAH patients' evolution included in the local registry was monitored for 1 year of specific vasodilator therapy (Bosentan/Ambrisentan/Sildenafil). We evaluated the effort tolerance (through 6 minutes walking test - 6MWT, dyspnea scale Borg, functional class) and body composition (evaluated through impedantometry).
Results: 7 adult patients with IPAH (5 female, 71.42%), average age 41.14 ± 7.7 years were monitorized, majority with severe forms (71.42%), Nyha Class III (57,14%).The 6MWT was slightlylower initially(452.2 m, 76.6% of normal value) and remained almost unchanged (447.8m, 75.4% of normal value). The BMI was normal on 4 patients, 2 patients were with cachexia and one patient was with obesity ( the average BMI/group was 23.10 and remained almost unchanged, 23.24). Body composition was altered in all patients. The proteins were reduced in 5 patients (8.5 kg average / group and after one year fell to 8.1kg). The percent of body fat was high on 4 patients (27.08% average/group and rose to 28.64%), total body water was high on 2 patients (30.74l average/group and rose to 31.72l). Abdominal circumference increased in 4 patients.
Conclusions: Body composition is early altered in IPAH patients and may be a prognosis indicator.
- © 2014 ERS