Skip to main content

Main menu

  • Home
  • Articles
    • Current issue
    • ERJ Early View
    • Archive
  • About
    • About continuous publication
    • Journal information
    • Editorial Board
    • CME
    • Press office
    • Permissions and reprints
    • Advertising
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS author centre
  • For readers
    • Alerts
    • Subjects
    • Podcasts
    • RSS
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Articles
    • Current issue
    • ERJ Early View
    • Archive
  • About
    • About continuous publication
    • Journal information
    • Editorial Board
    • CME
    • Press office
    • Permissions and reprints
    • Advertising
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS author centre
  • For readers
    • Alerts
    • Subjects
    • Podcasts
    • RSS
  • Subscriptions

The efficacy of CPAP and oral appliances in moderate obstructive sleep apnoea, used as CBO guideline states

L. Visscher, M.G.J. Brusse-Keizer, M.M.M. Eijsvogel
European Respiratory Journal 2014 44: P2217; DOI:
L. Visscher
Pulmologoy, Medisch Spectrum Twente, Enschede, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.G.J. Brusse-Keizer
Epidemiology, Medisch Spectrum Twente, Enschede, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.M.M. Eijsvogel
Pulmologoy, Medisch Spectrum Twente, Enschede, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

In obstructive sleep apnea syndrome (OSAS) continuous positive airway pressure (CPAP) is considered in most guidelines as the reference treatment for OSAS, and mandibular repositioning appliance (MRA) as alternative therapy in patients with CPAP-failure. The Dutch OSAS guideline of 2009 states that, CPAP is the preferred treatment in severe (AHI >30) OSAS but MRA and CPAP have the same efficacy in moderate (AHI 15-30) OSAS. This statement has, however, never been evaluated in clinical practice.

This study is a retrospective observational non-inferiority study. The 1-year treatment success (AHI < 10) of CPAP and MRA for moderate OSAS has been compared. Due to the non-random assignment of the treatments and the associated differences in patient characteristics, treatment effects are corrected with a propensity score. The non-inferiority margin was defined at 25% difference in treatment success rates, with an estimated success rate of 80% for CPAP, which is conform to an odds ratio of 3.27.

In 2011 31 MRA and 123 CPAP treatments where started in patients with moderate OSAS in our Dutch hospital. The OR of treatment success of CPAP versus MRA is 0.45 with a 95% CI of 0.137 to 1.45. Since this upper limit is below the inferiority threshold of 3.27, MRA is non-inferior to CPAP.

The 1-year efficacy of MRA is non-inferior to CPAP therapy in patients with moderate OSAS. The recommendation in the Dutch National OSAS guideline, to choose between MRA and CPAP in moderate OSAS, seems to be valid.

  • Sleep disorders
  • Treatments
  • Apnoea / Hypopnea
  • © 2014 ERS
Previous
Back to top
Vol 44 Issue Suppl 58 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The efficacy of CPAP and oral appliances in moderate obstructive sleep apnoea, used as CBO guideline states
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
The efficacy of CPAP and oral appliances in moderate obstructive sleep apnoea, used as CBO guideline states
L. Visscher, M.G.J. Brusse-Keizer, M.M.M. Eijsvogel
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2217;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
The efficacy of CPAP and oral appliances in moderate obstructive sleep apnoea, used as CBO guideline states
L. Visscher, M.G.J. Brusse-Keizer, M.M.M. Eijsvogel
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2217;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • The impact of CPAP on circulating IGF-1 in patients with OSAS
  • Does CPAP therapy affect sleep time in patients with obstructive sleep apnea? A prospective study
  • Comparison of peri-pharyngeal muscle recruitment during upper airway obstruction in patients with OSA and healthy subjects during wakefulness and sleep
Show more 4.2 Sleep and Control of Breathing

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Collections
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Fax: +44 114 266 5064
Email: info@ersj.org.uk

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2018 by the European Respiratory Society