Abstract
Introduction:We have already shown that 8weeks(wks) of quadriceps resistance training(RT) & post-exercise protein & carbohydrate supplementation(PCS) did not augment functional gains or molecular responses, from those seen with RT alone in COPD patients(Constantin et al.2013). Here we aimed to determine whether the responses to RT & PCS were different in sarcopenic(Sc) & non-sarcopenic(NSc) COPD patients.
Methods:This was a subgroup analysis involving 32subjects; 14were Sc, defined as having a height normalised appendicular lean mass(total lean mass of arms&legs/height2:kg/m2) of<7.23 men &<5.67 women(Cruz-Jentoft et al.2010).
RT consisted of 5x30 maximal isokinetic knee extensions at 180°/sec, 3x/wk for 8wks(Cybex). Subjects ingested a PCS after each RT session.
Isometric strength, isokinetic peak torque at 60°/sec(Cybex), thigh lean mass(DEXA) & work done during an incremental cardiopulmonary exercise test(CPET) were measured at baseline & after 4&8 wks of RT. Target proteins known to regulate muscle protein synthesis & breakdown were determined in quadriceps muscle samples taken at rest, at baseline & after 24 hours,4&8wks of RT.
Results:At 8wks, thigh lean mass(2.4 Vs 5.3%), isometric strength(15.1 Vs 20.4%), isokinetic peak torque(19.3 Vs 24.9%) & CPET work(21.8 Vs 18.1%) increased in the Sc and NSc groups respectively, there were no between group differences in the magnitude of response. Also, no between group differences were observed in the molecular responses to RT & PCS.
Conclusions:PCS did not influence functional or molecular responses to RT in Sc COPD patients when compared to NSc patients.
- © 2014 ERS