Abstract
Obesity is a risk factor for incident asthma in adults, and obesity is a major component of metabolic syndrome. This study aimed to explore the associations of metabolic syndrome and its components with the cumulative incidence of asthma in adults.
We conducted a prospective cohort study of participants who were asthma-free at baseline (n = 23 191) in the Nord-Trøndelag Health Study from 1995 to 2008. Baseline metabolic syndrome was categorised using the definition of the Joint Interim Statement from several international organisations. Incident asthma was self-reported at follow-up, which averaged 11 years.
Metabolic syndrome was a risk factor for incident asthma (adjusted OR 1.57, 95% CI 1.31–1.87). This association was consistent in sensitivity analyses using a stricter asthma definition (adjusted OR 1.42, 95% CI 1.13–1.79). Among the components of metabolic syndrome, two remained associated with incident asthma after mutual adjustment for the other metabolic components: high waist circumference (adjusted OR 1.62, 95% CI 1.36–1.94) and elevated glucose or diabetes (adjusted OR 1.43, 95% CI 1.01–2.04).
Metabolic syndrome and two of its components (high waist circumference and elevated glucose or diabetes) were associated with an increased risk of incident asthma in adults.
Abstract
Metabolic syndrome and two of its components were associated with an increased risk of incident asthma in adults http://ow.ly//p2RNy
Footnotes
This article has supplementary material available from www.erj.ersjournals.com
Support statement: This study was supported by the Research Council of Norway (project number 201895/V50) and the Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Conflict of interest: Disclosures can be found alongside the online version of this article at www.erj.ersjournals.com
- Received March 14, 2013.
- Accepted June 18, 2013.
- ©ERS 2013