Abstract
Obstructive sleep apnoea may be recognized a risk factor of diabetes type 2. The aim of this study was to assess an oral glucose tolerance test (OGTT) in OSA subjects. We studied 305 OSA pts [234 males (76.7%) and 71 females (23.3%)], mean age = 56.4±10.9 years, AHI = 42.2±20.9, BMI = 33.1±5.5 kg/m2). Impaired glucose tolerance (IGT) (plasma level ≥ 140 mg% after 2 hours of administration 75 g glucose) was found in 81 subjects (26.6%). Among them in 13 patients (4.3%) OGTT allowed to diagnose diabetes (glucose ≥ 200 mg%). Comparison of OSA patients with- and without IGT is shown in the table.
Multiple linear regression analysis confirmed significant correlation between AHI (ß=0.13, p=0.04), age (ß=0.21, p=0.0002), min SaO2 (ß= -0.18, p=0.035) and IGT.
Logistic regression revealed significant correlation between abnormal results of OGTT and arterial hypertension.
Conclusions: Impaired glucose tolerance was frequent in OSA subjects (near 30%). OSA patients with IGT were older and had higher prevalence of arterial hypertension. HBA1C is a good parameter of glucose metabolism in OSA patients.
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