Abstract
Brain natriuretic peptide (BNP) is a hormone secreted by the ventricles in response to heart overload. The aim of this study was to assess prevalence of elevated NT-proBNP (inactive form of BNP) level in OSA patients and its relations to echocardiographic parameters and OSA-asociated cardiovascular complications. We studied 87 OSA pts, mean AHI was 43.2±24.1, age - 57.5 ±10.6 yrs, mean plasma NT-proBNP level was 198.5±357.3 pg/ml. Elevated NT-proBNP concentration was found in 34 pts with OSA. Comparison of OSA pts with normal and elevated NT-proBNP level is shown in a table below.
Elevated NT-proBNP level was found in 39.8% OSA subjects. Logistic regression analysis revealed that elevated NT-proBNP level (>125pg/ml) did not correlate with studied echocardiographic parameters in OSA pts (p>0.05). NT-proBNP level negatively correlated with AHI (r =-0.25, p=0,02). Elevated NT-proBNP concetration indicated at increased risk of coronary artery disease (OR = 12.94, 95%CI = 2.4-68.5, p<0.01).
Conclusions: Increased plasma concentration of NT-proBNP was not related to echocardiographic parameters, but it was associated with occurence of CAD in OSA subjects.
- © 2012 ERS