Abstract
Untreated OSA is a risk factor for cardiovascular morbidity and mortality. Brain natriuretic peptide (BNP) is a hormone secreted by the ventricles in response to heart overload. The aim of this study was to assess plasma NT-proBNP (inactive form of BNP) in OSA subjects and relationship between hormone level and OSA severity and complications. We studied 1145 OSA pts (859 males-75% and 286 females-25%), mean age - 56.4±10.4 years, AHI – 39.6±21.6, BMI - 34,2±6,4 kg/m2. Increased NT-proBNP (> 125 pg/ml) was found in 294 subjects (25.7%). Comparison of OSA subjects with normal and elevated NT-proBNP is shown in a table.
Logistic regression analysis revealed that heart failure (OR- 4.4; 95%CI – 4.09-4.74; p<0.0001), atrial fibrillation (OR-4.22; 95%CI – 3.89-4.58; p<0.0001), coronary artery disease (OR-2.29; 95%CI – 2.16-2.43; p<0.0001), arterial hypertension (OR-1.87; 95%CI – 1.75-2.0; p<0.0001) and COPD (OR- 1.37; 95%CI – 1.27-1.47; p<0.0001) were independent predictors of increased NT-proBNP after adjusting for BMI, diabetes, hyperuricaemia and stroke.
Conclusions: Increased plasma NT-proBNP concentration in OSA subjects was mainly related to cardiovascular diseases.
- © 2012 ERS