Abstract
Background: In 2000, the French College of General Hospital Respiratory Physicians (CPHG) performed a prospective epidemiological multicentre study (KBP-2000-CPHG) which described the features of 5,667 primary lung cancers. Over the last 10 years, lung cancer management changed: new drugs, diagnostic techniques and TNM classification. The CPHG thus promoted a similar study: KBP-2010-CPHG.
Aims and objectives: To describe the characteristics and management of new cases of primary lung cancer; to evaluate 1, 4 and 5-year patient survival rates; to compare results with those of KBP-2000-CPHG.
Methods: Data were collected using a standardised form for all patients ≥18 years with a primary lung cancer, histologically or cytologically diagnosed between 1 January and 31 December 2010 and managed in a general hospital. A steering committee checked exhaustivity in each centre.
Results: 7,610 patients were enrolled in 119 centres. 6,083 patients (86.3%) had a NSCLC. The main characteristics of NSCLC patients were: mean age, 65.5 +/-11.4 years; 24.4% female; 11.9% non-smokers, 40.5% ex-smokers, 47.6% current smokers; 69.8% performance status 0 and 1. The main characteristics of the tumour were: 53.5% of adenocarcinoma, 31.0% of squamous-cell carcinoma, and 12.9% of large cell carcinoma; 18.1% stage IA to IIB, 14.0% stage IIIA, 9.5% stage IIIB and 58.3% stage IV. First-line treatments were: curative surgery, 19.0%; radiotherapy alone, 18.7%; combined radio-chemotherapy, 26.1%; and chemotherapy, 61.8%.
Conclusions: In 10 years, characteristics of NSCLC patients changed with a significantly increase (p<.0001) of women, non-smokers, adenocarcinoma histology and stage IV at diagnosis.
- © 2012 ERS