Abstract
In patients with COPD have a high risk of osteoporosis.The most convenient tool to detect osteoporosis is a method of estimating the 10-year risk of osteoporotic fractures FRAX, proposed in 2008, JA Kanis. Objective: To explore the practical application of FRAX method to assess the 10-year risk of osteoporotic fractures in patients with COPD. Materials and methods: We examined 108 patients with COPD. The study group comprised men with long smoking history. Mean age 60,2 ± 5,5 years. The study of respiratory function was performed on a multi-type installation «Master-Lab/Jaeger». The study of bone mineral density (BMD) of lumbar spine and proximal femur was performed by X-ray ab-sorbtsiometrii on densitometer «Lunar DPX-NT». Evaluation of ten major osteoporotic fracture risk and the risk of hip fracture was calculated using the computer program FRAX. To calculate the risk methodology used FRAX T-score femoral neck. Results: In assessing the absolute risk of major common fractures associated with osteoporosis, using a computer program FRAX, revealed that the minimal risk of major fractures observed in patients with COPD 2 stage- 3,25, the maximum - in patients with COPD 4 stage -7,4. The maximum risk of hip fracture was observed in patients with COPD 4 stage- 4,5. Established reliable correlation values of ten osteoporotic fracture risk, estimated by the method of FRAX with BMI (r -0,62, p <0,01), with DLCO, (r -0,46, p <0,05), with BMD (r -0,86, p <0,05). Conclusion: Patients with COPD stage 3 and 4 have a significantly higher risk of fractures compared with patients with COPD stage 2.
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