Abstract
INTRODUCTION: C - Reactive Protein (CRP), an early sensitive marker of inflammation is studied extensively in various common medical disorders.Until recently CRP measurement was not studied widely in Pneumonias .We intended to study its usefulness for assessment of disease severity in patients of Community acquired pneumonia (CAP) with Sepsis.
OBJECTIVE: To evaluate the utility of C - Reactive Protein as a marker of disease severity in patients of Community acquired pneumonia with Sepsis.
METHODS:
Study design: Prospective observational study.
Setting: 12 bedded ICU of a multi speciality hospital in Abudhabi, UAE.
Subjects: 40 patients admitted during June 2010 - January 2012, fulfilled the study criteria.
CAP and Sepsis were defined based on the ATS and ACCP/SCCM 1992 criteria respectively.
RESULTS: Patients were divided into two groups, Group A with CRP < 300 mg/ L and Group B with > 300 mg/ L with mean age being 36.5 and 42.6 years respectively. Characteristics of disease severity were compared in both the groups.
Presentation of septic shock, severe sepsis and multiorgan dysfunction was significantly higher in group B (p< 0.05).Mean CRP value among nonsurvivors was 355.33 mg/ L and 257.56 mg/L among survivors (p <0.05).
CONCLUSION: CRP value of greater than 300 mg / L within first 48 hours of admission in ICU appears to be a good marker of disease severity in patients of Community acquired pneumonia with Sepsis and may be useful to identify high risk patients.
- © 2012 ERS