Age >40 yrs | Known α1-antitrypsin deficiency |
FEV1 >15% and <45% pred | Evidence of either clinically significant asthma, chronic bronchitis or bronchiectasis |
TLC >100% pred | DL,CO <20% pred |
RV >150% pred | Post-rehabilitation 6MWD <140 m |
mMRC dyspnoea score ≥2 | Pneumothorax within previous 18 months |
Pa,CO2 <55 mmHg, Pa,O2 >45 mmHg while breathing room air | Procedures involving thoracotomy |
Nonsmoking for >4 months | Large bullae (>1/3 volume of lobe) |
Recent completion of pulmonary rehabilitation | Left ventricular ejection fraction ≤40% |
BMI ≥15 kg·m−2 or ≤35 kg·m−2 | Stroke, unstable myocardial ischaemia or ICD |
| Coagulopathy |
| Pulmonary hypertension (peak systolic Ppa ≥45 mmHg or mean Ppa ≥35 mmHg |
| Previous bronchoscopic LVR |