Abstract
In this study, we aimed to investigate the relation between bronchoprovocation test positivity an development of allergic respiratory disease.
The inclusion criteria to study were disease duration more than 1 year,no chronic urticaria exacerbation in two months, no history of long acting antihistaminic and corticosteroid usage in a month. The patients with asthma and pulmonary symptoms, disease causing positive methacholine provocation test (MPT), contraindication to the MPT, and abnormal pulmonary function test were excluded.
156 patients with chronic urticaria were included to the study. There was 108 (69,2%) female and the mean age was 42,54±13,19 years. The duration of disease was 6,05±4,33 (1-25) years.
After physical examination, pulmonary function test and MPT were performed to the all patients with chronic urticaria. At the beginning,MPT positivity was detected in 41 (26,3%) patients. There was no significant difference between patients with MPT(+) and MPT(-) according to demographic findings. Mean dose of MPT and total IgE level were 2,64±3,36 mg/dl and 123,3±124,3 respectively. In MPT(+) patients, rate of doctor diagnosed asthma and allergic rhinitis were 46,3% and 60,9% respectivelyand they were 18,2% and 25,2% respectively in MPT(-) patients (p<0.05). Presence of allergic disease in family members did not influence the development of these allergic respiratory diseases. Also total IgE level at the beginning did not related with develpment of these disease.
As a result,bronchoprovocation test can be (+) in chronic urticaria patients without pulmonary symptoms and this positivity can be first sign of respiarotory allergic disease that will develop in future.
- © 2011 ERS