Abstract
Background: COPD is often associated with the systemic extra pulmonary effects such as osteoporosis.
Aim and objectives: To study the dynamics of BMD in the course of COPD progression.
Material and methods: We examined 72 COPD male patients (aged 40-70 years). The COPD pts were subdivided into groups according to COPD severity: the 1st was made of 14 men; GOLD I stage; mean age 55 years; FEV1 78%; BMI 27 kg/m2, smokers 68%, packs/yrs 20; the 2nd included 43 patients; GOLD II stage; mean age 57; FEV1 63%; BMI 28 kg/m2, smokers 80%, packs/yrs 21; the 3d -20 patients; GOLD III stage; mean age 60; FEV1 41%; BMI 24,5 kg/m2, smokers 84%, packs/yrs 28. All the findings were compared in 34 normal age-, sex- and BMI-matched control subjects. BMD was measured in spine (L1-L4) and femoral necks (FN) in 106 men using DEXA.
Results: The level of BMD was significantly lower in 3d group in comparison with control both in spine (0,992±0,156 vs.1,252±0,119 g/CM2, p<0,01) and at femoral necks (0,824±0,136 vs. 0,985±0,065 g/CM2, p<0,01). Osteopenia and osteoporosis were diagnosed in 51% and 11% cases in the 2nd group; 30% and 60% in the 3d group respectively. Osteopenia was revealed in 50% patients in the 1st group.
We found the negative significant correlations between packs/yrs and BMD of L1-L4 (r=-0,55); with BMD of FN (r=-0,38).
Conclusions: The significant decrease of BMD was found in the course of COPD progression.
- © 2011 ERS