Abstract
Background: Long term aerobic training (AT) seems to decrease airway inflammation in mice with pulmonary allergic disease.
Objective: Investigate the effect of short on AT in a murine model of asthma.
Methods: Male Balb/c mice were divided in 4 groups: Control, AT, ovalbumin sensitized (OVA) and OVA+AT. Sensitized groups received OVA i.p. (days 0,14, and 28) and were exposed to inhaled OVA1% (30min/3xweek) after the 21th day. The AT protocol as performed in a treadmill and began in the 28th day and was performed for 7 days (1hr/session, 50% of maximal intensity). Evaluations: In vivo respiratory mechanic (Flexivent), differential cell counting in the BALF, and collagen fibers depositions and smooth muscle thickness airways were evaluated by an image analyzer.
Results: Physical capacity was increased just in trained groups (AT and OVA+AT; p<0.01). No change was observed in respiratory mechanic among all groups (p>0.05); however, it was observed an increase in inflammatory cell migration and collagen fibers, and smooth muscle thickness in OVA and OVA+AT groups (p<0.05).
Conclusions: Short term aerobic training seems do not decrease features of pulmonary allergic disease in mice.
- © 2011 ERS