Abstract
The impact of COPD phenotypes based on body composition and it's change was evaluated on longitudinal outcomes in COPD patients from the “Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints” (ECLIPSE) study.
We assessed the effect of low body mass index (BMI) (BMI <21 kg/m2) at Study Year 1 for 364 COPD patients and assessed the impact of BMI and the change in BMI from baseline to year 1 on mortality during the subsequent two years of the study. During the follow-up, there were 31 deaths. Using logistic regression, each decrease from baseline to Year 1of 1 kg/m2 in BMI in this underweight group was associated with a 51% increased risk of death after controlling for FEV1% predicted and BMI.
These findings suggest that for a group of underweight COPD patients, the magnitude of weight change in the previous year is an independent predictor of poor outcome.
Funded by GlaxoSmithKline (SCO104960, NCT00292552).
- © 2011 ERS