Background: Transplantation of trachea with revasculazation heavy hi-tech operation which is carried out with the individual centers, except for that after this procedure the patient should receive for life immunosupression.
Aims: To study an opportunity of use of a trachea received by methods of regenerative medicine for treatment of patients with total tracheal lesion.
Materials and methods: The female 25 y.o. with complaints to constant difficulty breath, weakness, cough.CT and endoscopy have revealed a picture of total cicatricial lesion of a trachea. Each 2-3 days patient required in bouginage of trachea. Indications to transplantation of a trachea are exposed. It was used cadaveric decellurilized trachea prepared by techniques of regenerative medicine. The total resection of a trachea was executed. Into a wall of a donor trachea are entered stem cells of the patient and factors of growth of cells. Anastomosis with own trachea were performed by vicryl 3/0. From abdomen the part of the big omentum was moved by which the donor trachea with anastomosis was completely covered.
Results: The early postoperative period was accompanied by the moderate respiratory insufficiency, hemoptysis, expressed bronchial secretion. By the moment of discharge breath was free, a gleam of trachea on all extent was satisfactory. Patient does not require immunosupression.
Conclusions: Regenerative medicine for preparation of the trachea with the aim of transplantation can cardinally change philosophy of thoracic surgery particularly in management of patients with total incurable stenoses of a trachea.
- © 2011 ERS