Abstract
Introduction: This study gathered information on genesis of MDR TB at 3 centers in India which helps understand the current clinical practice and management of MDR TB and helps to standardize diagnostic and therapeutic strategies relevant for resource poor setting.
Primary objective: To describe the clinical profile, of patients with MDR TB and suspect MDR TB patients in India and their out come.
Study design: Descriptive follow up study.
Study setting and population: Private and public health sector: Patients attending primary, secondary and tertiary health care centers in selected study areas in India.
Study period: 1st June 2007 to 30th May 2009.
Study Variables Clinical Outcome Measures: Cure - Patients treated for 18 - 24 months and who remain smear and culture negative; Likely cures - patients treated for at least 12 months, and who remain smear and culture negative; Absconders/Defaulters and Death.
Results: 344 cases,either suspect or confirmed cases of MDR-TB from 3 different states in India were recruited. 71 cases were culture +ve for MDR TB. 15.77%patients died. 59.54% of the patients had far or moderately advanced chest X-ray lesions. The BMI of patients who died was less than 20 (87%). 27.4% of the patients who died had diabetes.75% were males. Smoking index was moderate to heavy for 25%.More than 50% of the patients were aged between 30 - 50. 58% of patients had previous treatment with 4 drugs and 10% had received second line drugs. 67% of the patients utilized government facility for their treatment. With proper treatment success was > 60%.
Conclusion: MDRTB if not treated can lead to early death among patients with low BMI, Diabetes Mellitus and far advanced chest X ray lesions.
- © 2011 ERS